The Bible tells us that God gave Adam several commands and instructions. Here are some of the main ones:
* Be fruitful and multiply, and fill the earth and subdue it; and have dominion over the fish of the sea and over the birds of the air and over every living thing that moves upon the earth." (Genesis 1:28) This is a blessing and a command to populate and manage the Earth.
* "You may freely eat of every tree of the garden; but of the tree of the knowledge of good and evil you shall not eat, for in the day that you eat of it you shall die." (Genesis 2:16-17) This is the famous prohibition regarding the Tree of Knowledge of Good and Evil, with a warning about the consequences of disobedience.
* God brought animals to Adam to name them. This demonstrated Adam's role and intellect (Genesis 2:19-20).
These are the primary direct communications from God to Adam that are specifically mentioned in the Book of Genesis.